Randomized trial of pegylated interferon alfa2a versus. The active substance, peginterferon alfa2a, is a covalent conjugate of the protein. Therefore, the dose of zidovudine may need to be reduced by as much as 75%. Women must use birth control while taking peginterferon alfa2a.
It is not known whether interferon alfa2a passes into breast milk. Injection, interferon, alfa2a, recombinant, 3 million units drugs administered other than oral method, chemotherapy drugs j92 is a valid 2020 hcpcs code for injection, interferon, alfa2a, recombinant, 3 million units or just interferon alfa2a inj for short, used in immunosuppressive drugs. Interferon alfa2a article about interferon alfa2a by the. Pegasys is indicated for the treatment of hepatitis b envelope antigen. Pegasys peginterferon alfa2a package leaflet l03ab11. This use is approved for the sylatron brand of peginterferon alfa 2b.
Interferon alfa2a article about interferon alfa2a by. Interferons alfa2a and 2b differ at amino acid position 23. It is not known whether interferon alfa 2a passes into breast milk. Ifnl3 also known as il28b is a member of the type 3 ifnalpha family, which are induced by viruses and inhibit hcv replication in vitro. The biologic activity of peginterferonalfa2b derives from its interferon alfa2b moiety, which impacts both adaptive and innate immune responses against hepatitis c virus. Dailymed pegasys peginterferon alfa2a injection, solution. The strength indicates the quantity of the interferon alfa 2a moiety of peginterferon alfa2a without consideration of the pegylation. Food and drug administration fda for the treatment of chronic hepatitis b virus infection and chronic hepatitis c virus infection. Interferon alfa2b is an antiviral or antineoplastic drug.
Pegasys is often used together with another medication called ribavirin copegus, rebetol, ribapak, ribasphere, ribatab. Peginterferon alfa 2b is also approved to treat chronic hepatitis c. Interferon alfa2a is produced biosynthetically using recombinant dna technology and is the product of a cloned human leukocyte interferon gene. Interferon alfa 2a is produced biosynthetically using recombinant dna technology and is the product of a cloned human leukocyte interferon gene. For hepatitis c it is typically used together with ribavirin and cure rates are between 24 and 92%. Peginterferon alfa2a pegasys treatment hepatitis c online. Pegylated interferonalfa2a induces complete hematologic and.
Pegasys, innpeginterferon alfa2a european medicines agency. A box containing 180 mcg per 1 ml solution in a singledose vial. Pediatric patients treated with peginfalfa2a plus ribavirin showed a delay in weight and height increases. It is a manmade form of a natural substance called interferon. Drug approvals by the medicines control council in south africa containing interferon alfa2a. It is given by injection under the skin side effects are common. Interferon is a protein that modifies the response of the bodys immune system to help fight infections and severe diseases. Pegasys contains the active substance peginterferon alfa 2a, which is a longacting interferon. Pegasys peginterferon alfa 2a is made from human proteins that help the body fight viral infections used to treat chronic hepatitis b or c. After treatment has ended, normal hair growth should return.
The subject will be randomized into one of two study regimens, either pegylated interferon alfa 2a pegasys or aspirin and hydroxyurea also called hydroxycarbamide. Pediatric patients treated with peginf alfa 2a plus ribavirin showed a delay in weight and height increases. The first study is designed to provide clinical data on the use of victrelis boceprevir, an oral hcv ns34a protease inhibitor, in combination with mericitabine ro5024048, roches investigational oral hcv ns5b nucleoside polymerase inhibitor, pegasys pegylated interferon alfa2a and copegus ribavirin, in adult patients with chronic hcv genotype 1 infection who. The peg moiety is linked at a single site to the interferon alfa moiety via a stable amide bond to. The study subject will be followed for their condition for about 5 years. Peginterferon alfa 2a may cause or worsen the following conditions, which may be serious or cause death. This medicine has similar actions to natural interferons and is used to treat aidsrelated kaposis sarcoma, certain types of hepatitis or certain cancers. It is used as adjuvant therapy in patients who have had surgery to remove cancer that has spread to the lymph nodes. It is used to treat chronic hepatitis b and chronic hepatitis c, which are diseases of the liver. Interferon alfa2a, interferon alfa2b, peginterferon beta1a, and interferon beta1b may increase blood levels of zidovudine azt, retrovir. Interferon alfa2b definition of interferon alfa2b by. Pegasys peginterferon alfa2a information for patients genentech. Comparison of peginterferon alfa2a and alfa2b for treatment.
Peginterferon alfa2a is used to treat chronic hepatitis b or. After application of the exclusion criteria, 12,706 patients 3,578 1,710 males, 1,868 females on pegifn alfa2a. Peginterferon alfa2b wikimili, the best wikipedia reader. Peginterferon alfa2a side effects, dosage, interactions. Indication pegasys peginterferon alfa2a, as part of a combination regimen with other hepatitis c virus hcv antiviral drugs, is indicated for the treatment of adults with chronic hepatitis c chc with compensated liver disease. Pegasys injection contains the active ingredient peginterferon alfa 2a, which is a type of medicine called an immunomodulator. Peginterferon alfa2a wikimili, the free encyclopedia. The subject must be newly diagnosed or already receiving treatment for either pv or et. Peginterferon alfa2a peg in ter feer on al fa too aye brand name. Peginterferon alfa2a is also used to treat chronic hepatitis b infection. Compared to other interferon alfa subtypes, interferons alfa 2a and 2b both have a deletion at position 44 in the amino acid sequence. They may include headache, feeling tired, depression. The subject will be randomized into one of two study regimens, either pegylated interferon alfa2a pegasys or aspirin and hydroxyurea also called hydroxycarbamide. Peginterferon alfa2a is made from human proteins that help the body fight viral infections.
Interferon alfa, when used in combination with ribavirin, must not be used during pregnancy by either the pregnant woman or her male partner. Interferon alfa 2b is commonly prescribed in a kit with ribavirin. Despite a lower exposure to peginterferon alfa2a with the 5 mcg dose, subjects with esrd had a high rate of adverse events and discontinuations of pegasys in the trial. Pegasys is a sterile, preservativefree, colorless to. Peginterferon alfa 2a works by helping the immune system fight the hepatitis b and c virus, and by making it harder for the virus to reproduce within the body. This medication reduces the amount of hepatitis c virus in the body and helps the bodys immune system fight the infection. Peginterferon alpha pegifn 2a and 2b, or pegifn alpha, in combination with ribavirin, is used to treat hepatitis c virus hcv infection. Pegasys peginterferon alfa2a is made from human proteins that help the body fight viral infections used to treat chronic hepatitis b or c. Andrew karpenko, university of washington figure 3. Find patient medical information for interferon alfa2a injection on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
Pegasys, peginterferon alfa2a, is a covalent conjugate of recombinant alfa2a interferon approximate molecular weight mw 20,000 daltons with a single branched bismonomethoxy polyethylene glycol peg chain approximate mw 40,000 daltons. Interferon alfa2a is produced using recombinant dna technology in which a cloned human leukocyte interferon gene is inserted into and expressed in escherichia coli. It is sometimes called consensus interferon because it is a combination of interferon alfa 2a roferona or pegasys in the pegylated form and interferon alfa2b intron a or pegintron in the pegylated form. Pegasys contains the active substance peginterferon alfa2a, which is a longacting interferon. Pegasys, peginterferon alfa2a, is indicated for the treatment of adults with chronic hepatitis c who have compensated liver disease and have not been previously treated with interferon alfa. Interferon alfa2a definition of interferon alfa2a by. Interferon alfa2a is produced using recombinant dna technologyin which a cloned human leukocyte interferon gene is inserted into and expressed in escherichia coli. Pegylated interferonalfa2a induces complete hematologic.
Pegasys peginterferon alfa2a is a prescription medication that is. Interferon alfa2a south africa drug approvals medicines. Single use syringe peginterferon alfa2a pegasys photo. Peginterferon alfa 2a belongs to the class of medications known as interferons.
Genetic variants in ifnl3 are associated with increased response higher sustained virological response rate to. In study 6 n526, subjects received either roferona 6 miu three times a week for 12 weeks followed by 3 miu three times a week for 36 weeks or pegasys 180 mcg once weekly. Pegasys peginterferon alfa2a, as part of a combination regimen with other hepatitis c virus hcv antiviral drugs, is indicated for the treatment of adults with chronic hepatitis c chc with compensated liver disease. Peginterferon alfa 2a is also used to treat chronic hepatitis b infection. Peginterferon alfa2a oel fastrac with ade affygility. The first study is designed to provide clinical data on the use of victrelis boceprevir, an oral hcv ns34a protease inhibitor, in combination with mericitabine ro5024048, roches investigational oral hcv ns5b nucleoside polymerase inhibitor, pegasys pegylated interferon alfa 2a and copegus ribavirin, in adult patients with chronic hcv genotype 1 infection who had a null response to. Pegylated interferon alfa2a, sold under the brand name pegasys among others, is medication used to treat hepatitis c and hepatitis b. The apparent clearance of peginterferon alfa2a was similar between subjects with esrd and subjects with normal renal function. Baseline characteristics were generally similar between patients who received ribavirin and interferon alfa2a therapy and those who did not, with the exception that endstage renal failure was present in three patients who did not receive study treatment and in none who did. Do not use this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment. Use peginterferon alfa2a as ordered by your doctor. This is the same patient assistance program for the genetech manufactured ribavirin copegus.
Some people respond better to 2a and some to 2b, so. Peginterferon alfa 2a, also known as pegylated interferon alfa 2a, is a covalent conjugate of recombinant alfa 2a interferon with a single branched bismonomethoxy polyethylene glycol peg chain. Pegasys, peginterferon alfa 2a, is a covalent conjugate of recombinant alfa 2a interferon approximate molecular weight mw 20,000 daltons with a single branched bismonomethoxy polyethylene glycol peg chain approximate mw 40,000 daltons. Peginterferon alfa2a, injection, single use prefilled.
It is a recombinant form of the protein interferon alpha2 that was originally sequenced and produced recombinantly in e. Interferon alfa2a is in the fda pregnancy category c. List of drug approvals by the medicines control council in south africa containing interferon alfa 2a on. Interferon alpha is the generic name for the trade name drugs intron a, roferona. Roche pharmaceuticals, basel, switzerland was given by subcutaneous injection at a dose of 180.
Pharmaceutical benefits scheme pbs peginterferon alfa2a. Peginterferon alfa2b consists of interferon alfa2b covalently linked to a 12kd linear polyethylene glycol peg. For information about the safe and effective use of other hcv antiviral drugs to be used in combination with pegasys. Interferon alfa2b is commonly prescribed in a kit with ribavirin. Peginterferon alfa2a, also known as pegylated interferon alfa2a, is a covalent conjugate of recombinant alfa2a interferon with a single branched bismonomethoxy polyethylene glycol peg chain. Pegylated interferon alfa 2a, sold under the brand name pegasys among others, is medication used to treat hepatitis c and hepatitis b. Side effects of pegasys peginterferon alfa2a, warnings, uses. Interferons help your bodys immune system respond to bacteria, viruses, cancer, or other invading substances. Peginterferon alfa2b is also approved to treat chronic hepatitis c.
Peginterferon alfa 2b consists of interferon alfa 2b covalently linked to a 12kd linear polyethylene glycol peg. Pegasys 90mcg solution for injection in prefilled syringe. A total of 16,349 patients were recorded in the japanese interferon database. Peginterferon alfa2a pegasys, hoffmannla roche 180 mcg as vial or. The pbac accepted the submissions nomination of lamivudine as the main comparator. Compared to other interferon alfa subtypes, interferons alfa2a and 2b both have a deletion at position 44 in the amino acid sequence. Ribavirin and interferon alfa2a for severe middle east. Interferon alfa2b side effects, dosage, interactions. Nov 09, 2018 interferon alfa 2b is made from human proteins. This means that it is not known whether interferon alfa 2a will be harmful to an unborn baby.
Excipient information presented when available limited, particularly for generics. Infergen is not yet available in the pegylated form. Asia, suggesting that viral hepatitis is a major driver of significant morbidity in low. Peginterferon alfa2a would provide an alternative first line treatment to lamivudine and interferon alfa2a in the treatment of chronic hepatitis b infection. Peginterferon alfa2a injection pegasys side effects. The peg moiety is linked at a single site to the interferon alfa moiety via a stable amide bond to lysine. Single use syringe peginterferon alfa 2a pegasys photo. Peginterferon alfa2b pegintron treatment hepatitis c. Peginterferon alfa2a, is a covalent conjugate of recombinant alfa2a interferon approximate molecular weight mw 20,000 daltons with a single branched bismonomethoxy polyethylene glycol peg chain approximate mw 40,000 daltons. Pegasys in combination with ribavirin is indicated for the treatment of chc in treatment. In some cases, health care professionals may use the trade names intron a, roferona or other names such as ifnalpha and alpha interferon when referring to the generic drug name interferon alfa.
Peginterferon alfa2b pegintron treatment hepatitis c online. It is not known if peginterferon can cure hepatitis c virus infections permanently eliminate the virus from your body. Pegasys 90mcg solution for injection in prefilled syringe summary. This means that it is not known whether interferon alfa2a will be harmful to an unborn baby. Dec 14, 2010 the study subject will be followed for their condition for about 5 years. It was developed at biogen, and ultimately marketed by scheringplough under the trade name introna. Interferons alfa 2a and 2b differ at amino acid position 23. This use is approved for the sylatron brand of peginterferon alfa2b. Nov 08, 2019 pegasys peginterferon alfa2a injection is a sterile, preservativefree, colorless to slightly yellowish solution administered subcutaneously. Peg interferon alpha pegifn 2a and 2b, or pegifn alpha, in combination with ribavirin, is used to treat hepatitis c virus hcv infection. The biologic activity of peginterferon alfa 2b derives from its interferon alfa 2b moiety, which impacts both adaptive and innate immune responses against hepatitis c virus. While this reaction may improve zidovudines effectiveness, it also may increase the risk of blood and liver toxicity.